The vaccine increases the number of antibodies that could attach to nicotine molecules and delays the effect of nicotine for the first ten minutes.
Cigarette Smoking - A Silent Killer-Facts, Passive Smoking & How to Quit
Smoking kills the smoker silently, pushing him towards serious illnesses, which slowly lead to death.
Smoking kills the smoker silently, pushing him towards serious illnesses, which slowly lead to death.
‘The primary therapeutic use of nicotine is in treating nicotine dependence in order to eliminate smoking with the damage it does to health.’
Vaccines that target the nicotine molecule itself would be an alternate strategy. Two candidates advanced into clinical trials recently. They ultimately failed -- but not without first yielding clues as to how scientists could improve upon them. Individuals in the trials who produced the highest levels of anti-nicotine antibodies were more likely to abstain from smoking for over six months. Kim D. Janda and colleagues wanted to build on this lead. The researchers designed a new vaccine that could increase the number of antibodies that could attach to nicotine molecules. Testing in mice found that the vaccine delayed the effects of nicotine within the first 10 minutes after injection. They also found that treated mice had lower concentrations of nicotine in their brains, which is where the drug exerts its effects. The researchers say future efforts will focus on further refining the vaccine formula to get it ready for potential clinical trials.
Nicotine Exposure in Pregnancy Increases Obesity Risk in Babies
Smoking and nicotine replacements during pregnancy increase chances of obesity and metabolic syndrome in offspring, finds new research from Canada.
Smoking and nicotine replacements during pregnancy increase chances of obesity and metabolic syndrome in offspring, finds new research from Canada.
Thirdhand Smoke Causes DNA Damage
New study sheds light on yet another ill-effect of smoking. Thirdhand smoke, the residual smoke left over on surfaces such as walls, floors and furniture, can be extremely dangerous to health.
New study sheds light on yet another ill-effect of smoking. Thirdhand smoke, the residual smoke left over on surfaces such as walls, floors and furniture, can be extremely dangerous to health.
Nicotine-Chomping Bacteria May Hold Key For Developing Anti-Smoking Drug
An enzyme from the Pseudomonas putida bacterium originally isolated from soil in a tobacco field consumes nicotine as its sole source of carbon and nitrogen.
An enzyme from the Pseudomonas putida bacterium originally isolated from soil in a tobacco field consumes nicotine as its sole source of carbon and nitrogen.
