Novel Compound can Treat Addiction by Warding-off Drug-related Memories

Scientists have found that a novel compound could treat addiction by warding off memories linked with the time of prior drug use.

Despite being abstinent for long periods of time, many addicts remain vulnerable to their own memories of drug use in the past.

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For example, exposure to the same environment in which they commonly used drugs - a contextual memory - can increase their craving for the drug dramatically and can lead to relapse.

"In this study, we found that after repeatedly giving cocaine injections to rats within a particular environment, the rats developed a strong preference for that environment over another environment where a placebo was given," explained M. Foster Olive, Ph.D., co-author and senior investigator.

He added: "Next, we treated the animals with an experimental drug called CDPPB, and found that it decreased the rats' preference for the cocaine-associated environment during subsequent tests."

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This is a process called extinction learning, whereby the compound helps the brain to create new associations instead of retrieving the old associations, in this case between the cocaine and the environment.

Olive said that this promising finding could help aid the development of new therapeutic treatments that could be used in conjunction with exposure therapy- a technique used to desensitize individuals to stimuli that invoke negative responses or emotions.

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John Krystal, M.D., Editor of Biological Psychiatry agrees and hopes that these findings can be expanded to other areas of work.

He said: "It will be interesting to see whether this approach extends to the treatment of cocaine abuse or other addictions. Further, it will be important to see whether mGluR5 agonists [like CDPPD] might play a role in the treatment of the extinction of other forms of maladaptive learning, such as the traumatic memories associated with posttraumatic stress disorder."

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The study is published in the latest issue of Biological Psychiatry.

Source-ANI
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