Novel diagnostic therapy for lung cancer can detect the disease early, paving the way for personalized medicine, reports a new study.

‘Lung cancer is the most common cause of cancer-related deaths globally, is tough to detect at early stages, making it challenging to treat.’

Selective recognition and imaging of oncogene-specific non-canonical DNA secondary structures (G-quadruplex-GQ structures) maintain great hope in the diagnostic (theranostic) treatment for cancer development. They have been challenging due to their structural dynamics and diversity.
Small molecule for careful recognition of BCL-2 GQ has been developed through novel hybrid loop stacking, groove binding mode with turn on far-red fluorescence response, and anti-cancer activity displaying the potential GQ-targeted lung cancer theranostics. 




The ministry stated that this methodology could be further utilized to develop cancer-type specific theranostic drugs with tremendous implications in personalized medicine. A patent application has now been filed for this invention.
Source-Medindia