Researchers from the Wistar Institute have found a potential therapeutic target that can help keep killer T cells in prime shape for fighting infection, cancer.
Fighting infection, even cancer, may become quite easy for the human body if everything goes the way researchers at the Wistar Institute expect it to go. They have developed a potential therapeutic target that enables the body’s immunity- keeper, the T cells, in great shape for fighting infection.
The research team has identified seven different receptors on T cells that can suppress immune responses during a long battle with an infectious pathogen or against developing cancer.
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The key finding is that these new receptors likely control different aspects of T cell responses, such as division or expansion, controlling viral replication, and local killing of infected cells versus secretion of long-range active antiviral proteins.
"This amount of control over T cells' response is remarkable. It suggests that layers of negative regulation exist on exhausted T cells from co-expression of multiple inhibitory receptors," Nature quoted him as saying.
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"We are starting to see a picture emerging of a really tuneable array of inhibitory receptors expressed on T cells.
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"This presents us with a great clinical opportunity. T cells have a lot of weapons at their disposal to control viral infection and most of them are disarmed when these cells become exhausted.
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The study appears in journal Nature Immunology.
Source-ANI
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