MGMT promoter methylation is associated with improved survival for patients with WHO Grade II Gliomas, according to a new research. This is the first study of its kind to validate the prognostic significance of MGMT promoter methylation in this patient population and treatment regimen.
Glioblastoma Multiforme | Astrocytoma Grade 4 - Types, Causes, Symptoms, Diagnosis, Treatment
Glioblastomas are tumors that arise from astrocytes that make up the supportive tissue of the brain. Glioblastomas are usually highly malignant.
Glioblastomas are tumors that arise from astrocytes that make up the supportive tissue of the brain. Glioblastomas are usually highly malignant.
‘An important predictor of treatment outcome among patients with cancer of the brain and spinal cord – glioma, has been identified. This predictor is known as MGMT promoter methylation.’
RTOG 0424 was the first study to prospectively validate MGMT promoter methylation in this setting, providing clinicians another tool to risk-stratify LGG patients moving forward," Stated Dr. Chakravarti. The initial report on NRG Oncology/RTOG 0424 established a three-year survival benefit for patients with WHO grade II gliomas who received a combination of temozolomide and radiation This analysis now provides overall survival and progression-free survival outcomes related to the MGMT promoter methylation. The study, designed using the MGMT-STP27 prediction model to calculate MGMT promoter methylation status from Illumina HM-450K data, used univariate (UVAs) and multivariable analysis (MVAs) Cox proportional hazard models to determine the effect of MGMT status on survival outcomes.
Seventy-five of the 129 eligible trial participants from NRG Oncology/RTOG 0424 had MGMT status available. Fifty-seven (76.0%) of the patients with MGMT status available were methylated, whereas 18 (24.0%) were unmethylated. Results substantiate that MGMT promoter methylation is correlated with progression-free survival and overall survival and should be incorporated into future clinical trial designs.
Electroencephalogram (EEG): Diagnosis & Testing of Brain Disorders
An electroencephalogram (EEG) detects electrical activity in the brain using electrodes attached to the scalp.
An electroencephalogram (EEG) detects electrical activity in the brain using electrodes attached to the scalp.
Source-Eurekalert
Neurocysticercosis / Cysticercosis of Brain / Pork Tapeworm - Causes Symptoms Diagnosis Treatment FAQs
Neurocysticercosis or Cysticercosis of brain is the most common cause of epilepsy and the most common parasitic infection of the brain. Neurocysticercosis is more common in the developing countries.
Neurocysticercosis or Cysticercosis of brain is the most common cause of epilepsy and the most common parasitic infection of the brain. Neurocysticercosis is more common in the developing countries.
About Brain Tumor
Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. Brain tumors account for about 2.4% of all the tumor diagnosesandare most challenging due to their critically delicate location.
Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. Brain tumors account for about 2.4% of all the tumor diagnosesandare most challenging due to their critically delicate location.
