Obesity May Up Colorectal Cancer Risk in Younger Women

Obesity and weight gain were linked to higher colorectal cancer (CRC) risk among women below 50 years, reveals a new study.

Obesity was associated with a higher risk of early-onset colorectal cancer (CRC) among women younger than 50, reports a new study.

New cases of CRC and death are increasing among people younger than 50, and the reasons for this are largely unknown. This study used data from a large group of women in the Nurses' Health Study II to examine the association of obesity with CRC diagnosed before age 50.

Colorectal Cancer - Types, Causes, Risk Factors, Symptoms, Diagnosis, Treatment, Prognosis & Prevention
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third most common cancer in men.

‘Women who are obese or overweight have a higher risk of developing colorectal cancer (CRC) before 50 years.’
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The study included 85,256 women ages 25 to 42 who were free of cancer and inflammatory bowel disease when they enrolled in the study and followed up from 1989 through 2011.

Current body mass index (BMI), BMI at age 18 and weight gain since age 18 (exposures); relative risk, which is a statistical measure of probability, for new early-onset CRC (outcome).

This was an observational study. Researchers were not intervening for purposes of the study and cannot totally control for all the natural differences that could explain the study results.

Obesity - Causes, Symptoms, Diagnosis, Complications, Treatment
Obesity is a condition where there is excess accumulation of body fat which poses a risk to the health of the individual. It can affect children and adults.

The authors of the study are Yin Cao, M.P.H., Sc.D., of the Washington University School of Medicine, St. Louis, Missouri, and coauthors

There were 114 cases of early-onset CRC among the 85,256 women studied. Higher current BMI, BMI at age 18 and weight gain since early adulthood were associated with increased risk of early-onset CRC.

Colorectal Cancer Screening
Colorectal screening is done using tests to detect blood in stool, colonoscopy or sigmoidoscopy ordouble contrast barium enema or CT colonography.

Obesity, which is a BMI of 30 or above, was associated with the highest risk. The limitations of the study included mainly white women, so the findings need to be validated among other races/ethnicities and among men.

Obesity and weight gain since early adulthood were associated with increased risk of early-onset CRC. This study highlights the importance of weight control throughout life and the potential role of body weight in complementing CRC screening for the early detection of early-onset CRC.

Obesity during Pregnancy: Know the Risks
Women with a body mass index >30 are obese and are at a higher risk for gestational diabetes during pregnancy. Macrosomia and birth defects are risks seen in the babies.

Source-Eurekalert