More Than One Antibiotic Offers No Advantage For Treating Staph

Researchers from The University of Queensland, along with global counterparts, have found using two antibiotics to treat MRSA infection provides no advantage over using a single antibiotic.

Methicillin-resistant staphylococcus aureus (MRSA), the deadly super-bug, also called as golden staph, may not get killed by using more than one antibiotic, according to a new three-year multi-centre clinical trial involving 352 patients at 27 hospitals in Australia, Singapore, Israel and New Zealand.//

UQ Professor David Paterson said researchers tested whether adding a second antibiotic for seven days to a standard antibiotic treatment would lead to improved health outcomes after 90 days.

‘Using two antibiotics for resistant staphylococcus may not decrease mortality, bacteria in the blood, infection relapse or treatment failure. It only increases the incidence of side effects. ’
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"We found no significant difference in mortality, bacteria in the blood, infection relapse or treatment failure," Professor Paterson said.

"Furthermore, patients who received two antibiotics had a higher rate of side effects related to kidney function than those who received just one antibiotic.

"For many years doctors have debated whether MRSA should be treated with two antibiotics or just one antibiotic.

MRSA “Super bug” – Symptoms - Risk Factors – Diagnosis - Treatment
MRSA infection is the most dreaded hospital or community acquired infection that can become life-threatening.

"This trial now puts that debate to rest and will have a huge impact on how antibiotics are used for MRSA infections worldwide.

"These findings are hugely important on a number of levels - one of the most important implications of the research is how it can impact antibiotic use and the global issue of antibiotic resistance."

MRSA is a common and very serious cause of infection that affects more than 10,000 people in Australia every year, especially women aged 60 and over.

Treating the infection can take up to several months and requires lab testing for diagnosis.

Source-Eurekalert