Long-term functioning of transplanted kidneys is not possible if the kidneys are from donors with variants of a particular gene, reveals a study.
![Organ Donor`s Gene Variants Linked to Survival of Transplanted Kidneys Organ Donor`s Gene Variants Linked to Survival of Transplanted Kidneys](https://images.medindia.net/health-images/1200_1000/kidney2.jpg)
Researchers led by Barry Freedman (Wake Forest School of Medicine) looked for the potential link between APOL1 risk variants and shorter survival of transplanted kidneys in a larger group of patients. The new multi-center study included 675 deceased donor kidney transplants from African American donors.
Results from the study confirmed that 2 APOL1 gene variants in donor kidneys were associated with more than a 2-fold increased risk of organ failure after transplantation.
"These results warrant consideration of rapidly genotyping deceased African American kidney donors for APOL1 risk variants at the time of organ recovery," said Dr. Freedman. "APOL1 genotype data should be incorporated in the organ allocation and informed-consent processes."
Study: "Apolipoprotein L1 Gene Variants in Deceased Organ Donors Are Associated with Renal Allograft Failure" (Abstract TH-OR165)
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Source-Newswise