The most common malignancy of bone is metastatic disease, affecting approximately 400,000 people in the United States each year.
Promising Result for HER2-positive Metastatic Disease Via New Therapy
A new type of breast cancer treatment has shown encouraging activity as a first-line therapy in HER2-positive metastatic disease, researchers have said.
A new type of breast cancer treatment has shown encouraging activity as a first-line therapy in HER2-positive metastatic disease, researchers have said.
‘A problem arises when an osteoblastic lesion does not have typical features of a benign entity, such as an enostosis.’
"While imaging has become an integral part of diagnosing patients presenting with malignancy, it can be confusing when an osteoblastic lesion is identified in the presence and absence of a primary malignancy," said Connie Y. Chang, Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital in Boston. "As CT use has increased, the frequency of incidentally detected lesions has also increased". Chang is the corresponding author associated with the retrospective study, "Distinguished Untreated Osteoblastic Metastases from Enostoses Using CT Attenuation Measurements".
The study group comprised 62 patients with 279 sclerotic bone lesions found at CT (126 enostoses in 37 patients and 153 metastases in 25 patients). While the authors admitted that the sample size was small, the study concluded that a mean CT attenuation of 885 Hounsfield units (HU) and a maximum attenuation of 1050 HU provide reliable thresholds below which a metastatic lesion is the favored diagnosis. The HU is a quantity commonly used in CT scanning to express CT numbers in a standardized and convenient form.
Certain Gastrointestinal Tumors Associated With Higher Mortality Than Expected
Researchers have determined that certain gastrointestinal stromal tumors (GISTs) are more deadly than previously reported in medical literature.
Researchers have determined that certain gastrointestinal stromal tumors (GISTs) are more deadly than previously reported in medical literature.
Source-Eurekalert
Melanoma Progression and Survival Influenced by Inherited Gene Variants
While representing only four percent of all skin cancers, melanoma accounts for 80 percent of skin cancer deaths.
While representing only four percent of all skin cancers, melanoma accounts for 80 percent of skin cancer deaths.
Biomarker Linked To Drug Response In Refractory Urothelial Cancer, Keyed
Antiangiogenic drug pazopanib has evidenced clinically significant activity in patients with refractory urothelial cancer, states results presented at the AACR Annual Meeting 2012.
Antiangiogenic drug pazopanib has evidenced clinically significant activity in patients with refractory urothelial cancer, states results presented at the AACR Annual Meeting 2012.
