A major challenge in the field of neurodegeneration is the unclear understanding of neuronal dysfunction.
Scientists Provide New Insight into Protein Misfolding in Neurodegenerative Disorders
At the University of Southampton, researchers has provided new insight into the consequence of accumulated 'misfolded proteins' in neurodegenerative disorders, such as Prion and Alzheimer's disease.
At the University of Southampton, researchers has provided new insight into the consequence of accumulated 'misfolded proteins' in neurodegenerative disorders, such as Prion and Alzheimer's disease.
‘PERK, and its downstream substrate eIF2, are pathologically, genetically, and molecularly linked to several neurodegenerative disorders.’
PERK, and its downstream substrate eIF2, are pathologically, genetically, and molecularly linked to several neurodegenerative disorders. The active form of PERK, pPERK, is chronically upregulated in tauopathies such as Alzheimer's, Fronto-temporal dementia linked to chromosome 17, and Progressive Supranuclear Palsy (PSP). Genetically, a single nucleotide polymorphism in the gene coding for PERK, EIF2AK3, is associated with risk for PSP. Molecularly, pathogenic protein aggregates alter ER homeostasis triggering sustained PERK activation. Despite the reparative nature of its activity, long-term PERK activity activates pro-apoptotic cascades.
The objective of the review is to highlight the impact of PERK in neurodegenerative processes and underscore the pathway as a reservoir of therapeutic targets. To this end, current efforts attempting to inhibit PERK in in vivo models of tauopathy and prions have shown promising results. Therefore, PERK inhibition in these diseases is a promising therapeutic strategy, and efforts to develop optimal PERK inhibitors for the clinic are underway.
Saga of Autophagy and Neurodegenerative Disorders
From eukaryotic microorganisms to humans, autophagy is a highly conserved process through the evolution of species.
From eukaryotic microorganisms to humans, autophagy is a highly conserved process through the evolution of species.
Gene Responsible for Childhood Neurodegenerative Disorders Identified
Mutated gene responsible for three forms of leukodystrophies has been identified by scientists.
Mutated gene responsible for three forms of leukodystrophies has been identified by scientists.
Chinese Herb may Now Help Treat Neurodegenerative Disorders
A new study has finally approved the use of 5-hydroxymethylyfurfural for the treatment of neurodegenerative disorders and other oxidative injury related diseases of the brain
A new study has finally approved the use of 5-hydroxymethylyfurfural for the treatment of neurodegenerative disorders and other oxidative injury related diseases of the brain
