Plant-derived Compounds Could Help in Cancer Fight

Garlic, broccoli, medicinal-plants derived compounds could offer protection against breast cancer, states study.

In multiple presentations Sunday at the American Association for Cancer Research (AACR) Annual Meeting 2014, UPCI scientists will update the cancer research community on their National Cancer Institute (NCI)-funded findings, including new discoveries about the mechanisms by which the plant-derived compounds work.

Breast Cancer - Prevention and Management with Lifestyle Changes
Lifestyle choices may or may not cause breast cancer but healthy lifestyle changes can open up avenues beyond breast cancer. Good habits will allow one to fight breast cancer and to live with dignity.

At the AACR poster session "Mechanisms of Chemoprevention," Shivendra Singh, Ph.D., UPMC Chair in Cancer Prevention Research and professor in Pitt's Department of Pharmacology and Chemical Biology, will oversee four presentations by Pitt pharmacology and chemical biology researchers on plant-derived compound discoveries in his laboratory.

Dr. Singh will discuss how withaferin A, derived from an Indian medicine plant, binds to tubulin, a well-known target for drug treatment in breast and other cancers. This compound binds tubulin in the cancer at a site distinct from those affected by other clinically used tubulin targeting agents. Notably, this effect of withaferin A is selective for cancerous breast cells.

Eun-Ryeong Hahm, Ph.D., will discuss how diallyl trisulfide, an oil-soluble molecule created by chewing of allium vegetables, such as garlic, decreases levels of the estrogen receptor-alpha protein in breast cancer cells and inhibits growth of breast cancer stem cells by decreasing levels of two other proteins.

Can Garlic Control High Blood Pressure / Hypertension
Want to know how to lower high blood pressure/hypertension? Garlic is a miracle herb that helps to lower blood pressure and keep it under control.

Su-Hyeong Kim, Ph.D., will discuss how benzyl isothiocyanate, a molecule found in edible cruciferous vegetables, such as garden cress, works in breast cancer cells to decrease levels of Bmi-1, a protein that controls genes responsible for cell proliferation.

Anuradha Sehrawat, Ph.D., will discuss how breast cancer stem cell growth is inhibited when a protein called Ron sensitizes the stem cells to the benzyl isothiocyanate molecule in cruciferous vegetables. The molecule then induces breast cancer stem cell death.

Macrobiotic Diet - Yin and Yang Food - Advantages - Disadvantages - Theories
Macrobiotics is an Oriental theory that lays down guidelines for promoting well-being and longevity through systematic diet consisting mainly of whole grains and beans.

Source-ANI

Increased Risk of Developing Lung Cancer After Radiotherapy for Breast Cancer: Study
A new research finds women who undergo radiotherapy for breast cancer are at an increased risk of subsequently developing a primary lung tumor.