Over-expression of SLC6A14 protein in pancreatic tumors taken from patients and in cancerous pancreatic cells lines compared with normal pancreatic tissue.
Pancreatic Cancer - All About the Disease, its Diagnosis and Management
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
‘A blocker of SLC6A14, called α-methyltryptophan, induced amino acid starvation in pancreatic cancer cells and reduced the growth and proliferation of these cells, both in laboratory dishes and in mice.
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"Finally, a novel strategy to treat pancreatic cancer: starve it to death!" said Dr. Yangzom Bhutia, senior author of the British Journal of Pharmacology study. "Pancreatic cancer recruits the transporter SLC6A14 to satisfy its increasing demands for amino acids; our studies show that if we block this transporter with a drug, we can effectively starve this cancer to death."
Source-Eurekalert
Quiz on Pancreatic Cancer
Pancreatic cancer is often diagnosed at a late stage and can be fatal. Test your knowledge on pancreatic cancer by taking this quiz.
Pancreatic cancer is often diagnosed at a late stage and can be fatal. Test your knowledge on pancreatic cancer by taking this quiz.
Marine Sponge Could Hold the Cure for Pancreatic Cancer
The marine compound found in sea sponge not only kills cancer, cells but also has the ability to reduce pancreatic cancer tumor weight.
The marine compound found in sea sponge not only kills cancer, cells but also has the ability to reduce pancreatic cancer tumor weight.
Immune-Based Therapy Shows Promise Against Pancreatic Cancer
The three-drug combination - FAK inhibitors, immune therapy and chemotherapy - showed the best outcomes for survival rate in some mice.
The three-drug combination - FAK inhibitors, immune therapy and chemotherapy - showed the best outcomes for survival rate in some mice.
