Primary Insomniacs Use Increased Brain Activation Than Normal Sleepers, During Working Memory Task

A new study says that patients suffering from chronic primary insomnia (PIs) have higher levels of brain activation compared to normal sleepers during a working memory test.

The research abstract has been presented at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies.

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Results show that PIs use increased brain activation relative to good sleepers during the working memory task, particularly in areas responsible for visual-spatial attention and coordination of cognitive processes. This activation may explain how PIs maintain performance on the task despite their sleep difficulties.

PIs also were found to have decreased activation in visual and motor areas, which may suggest that PIs have higher baseline activation in these regions relative to good sleepers.

According to principal investigator Henry Orff, MS, at the University of California in San Diego, Calif., these findings show that PIs, like individuals who are acutely sleep deprived, may be able to maintain performance on different tasks if they are able to compensate with increased brain activation.

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"The good news is that patients with insomnia are probably able to function well in their daily lives and likely do not show significantly impaired performance," said Orff.

"That said, patients may have to work, concentrate, and attend more to tasks than people who sleep well," the expert added.

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The study included 12 people with primary insomnia (six females) with an average age of 39.4 years, and nine good sleepers (four females) with an average age of 35.7 years.

Performance was compared between the two groups on a working memory task. Functional MRIs (FMRI) taken during the task also were compared. Behavioral performance was measured by reaction time for correct responses, number of correct responses, and number of errors committed.

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