Research team have discovered a new protein target that may slow the progression in Duchenne muscular dystrophy.
Muscular Dystrophy / Duchenne Muscular Dystrophy - Overview
Overview about muscular dystrophy, a muscle disease characterized by muscle weakness and muscle wasting.
Overview about muscular dystrophy, a muscle disease characterized by muscle weakness and muscle wasting.
‘COUP-TFII protein - new target for treating progressive muscle wasting in Duchenne muscular dystrophy identified.’
This month in the JCI, work led by Ming-Jer Tsai at Baylor College of Medicine has identified a protein involved in coordinating the function of muscle precursor cells. In a mouse model of Duchenne muscular dystrophy, abnormally high levels of COUP-TFII exacerbated symptoms of muscle deterioration and diminished recovery after muscle injuries.
These symptoms were linked to decreases in muscle precursor cell function. In contrast, reducing COUP-TFII activity decreased muscle degeneration in the mouse model.
Quiz on Muscular Dystrophy
Muscular dystrophy is a condition that affects muscles and sometimes severely disables the patient. Duchenne muscular dystrophy is the most common type of muscular dystrophy. Would you like to test your knowledge on this particular disease? Here is a simple quiz to brush up your basics on this condition.
Muscular dystrophy is a condition that affects muscles and sometimes severely disables the patient. Duchenne muscular dystrophy is the most common type of muscular dystrophy. Would you like to test your knowledge on this particular disease? Here is a simple quiz to brush up your basics on this condition.
Source-Eurekalert
Duchenne Muscular Dystrophy Drug (Ataluren) Will be Available on NHS
Ataluren(Translarna) to be made available in National Health Services for treatment of Duchenne Muscular Dystrophy in children below the age of 5.
Ataluren(Translarna) to be made available in National Health Services for treatment of Duchenne Muscular Dystrophy in children below the age of 5.
Muscle Cells from Muscular Dystrophy Patients Offer Clues to Variations in Symptoms
To figure out what all of those mutations have in common, Johns Hopkins researchers have analyzed gene and protein activity in the lab-grown myoblasts.
To figure out what all of those mutations have in common, Johns Hopkins researchers have analyzed gene and protein activity in the lab-grown myoblasts.
