Protein binding molecule, Gbeta which otherwise halts cellular function is found to stimulate beta cells of the pancreas and facilitate insulin secretion.
![Protein Complex Gbeta5-RGS Found To Stimulate Insulin Secretion Protein Complex Gbeta5-RGS Found To Stimulate Insulin Secretion](https://images.medindia.net/health-images/1200_1000/diabetes-for-health.jpg)
‘Gbeta5-RGS protein complex which is known for halting cellular function is necessary for stimulation of insulin secretion.’
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"The role of this complex in insulin secretion is exactly opposite to what one could expect. We hope the insights from the current work will help us understand and treat the disorders that occur when these genes are broken." ![twitter](https://images.medindia.net/icons/news/social/twitter.png)
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In their study, Slepak and colleagues analyzed insulin production in two groups of mice -- one normal and another lacking the gene responsible for making the Gbeta5 protein. They found that the mice lacking this gene had much less insulin present in their blood.
The researchers then performed experiments on isolated pancreatic islets (insulin-producing organs) and on cells from which they also deleted the Gbeta5 gene. The results clearly demonstrated that Gbeta5-RGS is necessary for stimulation of insulin secretion. When the researchers put the gene back in place, the insulin secretion was restored.
Source-Eurekalert