An in-depth proteomic analysis of the sera of 50 participants from the Women's Health Initiative (WHI) hormone replacement therapy trial provides some explanations for the trial's clinical results.
An in-depth proteomic analysis of the sera of 50 participants from the Women's Health Initiative (WHI) hormone replacement therapy trial provides some explanations for the trial's clinical results. The study, published in Biomed Central's open access journal Genome Medicine, shows that estrogen upregulates proteins involved in several major body processes.
Samir Hanash, M.D., Ph.D., from the Fred Hutchinson Cancer Research Center, Seattle, worked with a team of researchers to identify and quantify proteins from 2,576,869 mass spectra, the largest serum protein data set obtained from a human observational study or clinical trial to date. He said, "Remarkably, as many as 10 percent of plasma proteins analyzed were found to be affected by estrogen hormone replacement therapy in post-menopausal women. These changes indicate a substantial effect on coagulation and metabolic proteins that may explain the increased risk of venous thromboembolism and stroke, and the reduced risk of fracture, found in the WHI trial."
What is Menopause?
Menopause is defined as the state of permanent cessation of menstrual cycles (periods) for 12-months.
Menopause is defined as the state of permanent cessation of menstrual cycles (periods) for 12-months.
Using the samples gathered one year after the initiation of therapy, they identified changes in serum levels of proteins directly involved in processes as disparate as osteogenesis, blood vessel morphogenesis, blood pressure regulation, immunity, inflammation and coagulation.
This work demonstrates the utility of comprehensive profiling of the serum proteome for clinical investigations. According to Hanash, "Our findings should encourage other investigators to include quantitative proteomic analysis as part of clinical trials of new therapies to better understand the effect of therapy and to identify surrogate markers of response to treatment."
Hormone Replacement Therapy – Liberation at a Cost
Hormone Replacement Therapy popularly known, as “HRT”is a means of replacing the sex hormones estrogen and often progesterone for post-menopausal women.
Hormone Replacement Therapy popularly known, as “HRT”is a means of replacing the sex hormones estrogen and often progesterone for post-menopausal women.
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Hormone Replacement Therapy May Trigger Breast Cancer in Post-menopausal Women
Research at the University of Missouri has revealed that a synthetic hormone present in Hormone Replacement Therapy (HRT) used by post menopausal women may lead to breast cancer.
Research at the University of Missouri has revealed that a synthetic hormone present in Hormone Replacement Therapy (HRT) used by post menopausal women may lead to breast cancer.
