'Re-engineered' Antibiotic to Kill Fatal Resistant Bacteria

A team of scientists has successfully reengineered an important antibiotic to kill the deadliest antibiotic-resistant bacteria.

A team of scientists has successfully re-engineered an important antibiotic to kill the deadliest antibiotic-resistant bacteria.

The compound could one day be used clinically to treat patients with life-threatening and highly resistant bacterial infections, researchers say.

Drug-Resistant Bacteria Commonly Seen in Afghan Patients
Study says Afghan patients treated at a U.S. military hospital in Afghanistan often carry multidrug-resistant (MDR) bacteria

"[These results] have true clinical significance and chart a path forward for the development of next generation antibiotics for the treatment of the most serious resistant bacterial infections," said Dale L. Boger, who is Richard and Alice Cramer Professor of Chemistry at The Scripps Research Institute and senior author of the new study.

"The result could not be predicted. It really required the preparation of the molecule and the establishment of its properties."

The compound synthesized is an analogue of the well-known commercial antibiotic vancomycin.

Significantly Fewer Antibiotic-Resistant Bacteria in Organic Poultry Farms
Antibiotic use in conventional animal food production in the United States has created public health concern because it has been shown to contribute to the development of antibiotic-resistant

The new analogue was prepared in an elegant total synthesis, a momentous achievement from a synthetic chemistry point of view.

"In addition to the elegantly designed synthesis," said Jian Xie, postdoctoral fellow in Boger's group and first author on the publication, "I am exceedingly gratified that our results could have the potential to be a great service to mankind."

New Technique Helps Target Antibiotic-resistant Bacteria
Scientists have developed a novel method which targets antibiotic resistant bacteria and protects patients from the toxic parts of an antibiotic drug.

The study has been published in the Journal of the American Chemical Society.

Source-ANI

How to Stem the Spread of Resistant Bacteria in Intensive Care
A commonly used strategy to reduce the spread of antibiotic-resistant bacteria in hospital intensive care units (ICU) had no significant effect, says a new research