Study Improves Understanding of Skin Physiology during Aging

New model of human reconstructed skin RHE from EPISKIN, showed that the formation of aggregates of proteins contributes to skin aging.

New study advanced the understanding of changes in skin physiology over the years and the consequent loss of skin sensoriality.

A study recently published in the scientific journal Neurobiology of Aging was done in partnership with researchers from L’Oréal Brasil, the D’Or Institute for Research and Education (IDOR), UFRJ, and EPISKIN.

‘New study throws light on the role of alpha-synuclein aggregates, suggesting that the agglomeration of these proteins in the skin may be related to an increase in its fragility with aging.’
Read More..

The researchers found that alpha-synuclein aggregates cause thinning of the skin because they trigger inflammation and reduce cell multiplication. Alpha-synuclein is a protein known to aggregate in the brain and damage certain regions that culminate in Parkinson's disease.

“Now we are revealing that this same protein can accumulate in the skin and cause a degeneration similar to aging,” revealed Marília Zaluar Guimarães, who leads the study together with Stevens Rehen, both from UFRJ/IDOR.

“It is possible that this accumulation is accelerated by exposure to ultraviolet, and that the sensory neurons themselves are the source of the protein”, says the researcher.

“The action of these clusters in the brain had already been identified as a causative agent for diseases such as Alzheimer's and Parkinson's disease. In 2019, L’Oréal scientists, in collaboration with McGill University, identified for the first time the presence of these clusters in the skin.”

“Our recent study sheds light on the role of these clusters suggesting that the agglomeration of these proteins in the skin may be related to an increase in its fragility with aging,says Rodrigo De Vecchi, CEO of Episkin in Brazil.

New Drugs Help Prevent Skin Aging
Two new drug molecules developed by researchers were found to prevent skin from aging after being exposed to ultraviolet light found in sunlight.

According to the study, these clusters can also impact sensory neurons in the skin, responsible for transmitting touch sensations to the brain, in addition to being related to the thinning of the epidermis, which is the outermost layer of our skin.

The changes that occur in the senses with age, such as loss of vision and hearing, are widely studied. However, the physiological changes in the skin and the tactile loss still need a better understanding.

The decrease in the sensoriality of the aging skin has psychological implications, such as the lack of feeling of well-being when applying a product or during a hug.

Moreover, the deterioration of this sensoriality can directly impact the quality of life exposing the subjects to additional risks related to a decrease in the perception of changes in temperature or textures added Dr. De Vecchi.

L'Oreal Group pioneered the development of reconstructed human skin as a key tool for skin and human tissue research. In 2017, in partnership with IDOR, L’Oréal introduced sensory neurons allowing the identification of the mechanism of action of these protein clusters.

This discovery opens the way for further research to understand the mechanisms to prevent the accumulation of these proteins throughout aging, as well as the development of products that stimulate the sensoriality of aged skin.

Source-Medindia