Researchers demonstrated for the first time the in vitro growth of a piece of spinal cord in three dimensions from mouse embryonic stem cells.
Syringomyelia | Hydromyelia | Syrinx: Causes Symptoms Diagnosis Treatment
Syringomyelia or hydromyelia is a rare neurological disorder where the person develops a fluid-filled cavity called syrinx in the spinal cord. Symptoms, diagnosis, treatment of syringomyelia are explained in detail.
Syringomyelia or hydromyelia is a rare neurological disorder where the person develops a fluid-filled cavity called syrinx in the spinal cord. Symptoms, diagnosis, treatment of syringomyelia are explained in detail.
For many years Elly Tanaka and her research group have been studying the regenerative potential of axolotls at the molecular level. The Mexican salamanders have the potential to regenerate their spinal cord and other organs to restore full functionality after injury. Mammals such as humans are not able to regenerate most organs. The restoration of the spinal cord in axolotl occurs in a three dimensional structure similar to an embryonic spinal cord. Due to their positions in the tissue, cells in the regenerated spinal cord know which function to perform in the restored tissue. "In this study we applied the knowledge gained about the regenerative potential in axolotls to a mammal, the mouse" explains Professor Elly Tanaka.
Single mouse embryonic stem cells embedded in a three-dimensional matrix and were grown in neural differentiation medium led to the clonal development of neuroepithelial cysts. These cysts settled in the midbrain and hindbrain along the neural axis. "Our goal, however, was to generate spinal cord in vitro," says Dr. Andrea Meinhardt, a postdoc at the CRTD. "For this reason we added retinoic acid to the culture medium on the second day of the 3D cell culture." The result not only caused the neural tissue to switch to spinal cord but also induced the formation of a local signaling center for forming all the different cell types of the spinal cord. "For the first time we could hereby reconstruct the structure of a typical embryonic neural tube in vitro," said Andrea Meinhardt.
Green Tea Protects the Brain During Spinal Cord Injury
In case of a spinal cord injury, the polyphenols in green tea can protect people's brain, reveals new research.
In case of a spinal cord injury, the polyphenols in green tea can protect people's brain, reveals new research.
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Susceptibility to bladder infections is high among people who have suffered spinal cord injuries.
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Previous research has shown that traumatic spinal cord injury (SCI) is a devastating condition with few treatment options.
Previous research has shown that traumatic spinal cord injury (SCI) is a devastating condition with few treatment options.
