Regulator of Chronic, Low-Level Inflammation Among Overweight Patients

The degree of chronic inflammation caused by obesity is highly dependent on levels of the signaling molecule, hydrogen sulfide.

Overweight people suffer from chronic low-grade inflammation primarily in fat tissue, which has been shown to cause insulin resistance and cardiovascular disease. A new study has now revealed that the degree of chronic inflammation caused by obesity is highly dependent on levels of the signaling molecule, hydrogen sulfide, which alters the activity of a calcium channel, Orai3.

These findings establish the possibility of targeting Orai3 as a novel treatment for the treatment of obesity-related inflammation, which has the added benefits of reducing insulin resistance and the likelihood of of developing type 2 diabetes.

Obesity - Causes, Symptoms, Diagnosis, Complications, Treatment
Obesity is a condition where there is excess accumulation of body fat which poses a risk to the health of the individual. It can affect children and adults.

‘The degree of chronic inflammation caused by obesity is highly dependent on levels of the signaling molecule, hydrogen sulfide, which alters the activity of a calcium channel, Orai3.’

This study was conducted by a team of Rosalind Franklin University researchers headed by Carl White, assistant professor of physiology and biophysics, and has been published in Science Signaling.

Source-Eurekalert

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