J. Meyle, Justus Liebig University, Giessen, Germany, will present an abstract titled P. gingivalis Infection and Immune Evasion of Oral Carcinomas
J. Meyle, Justus Liebig University, Giessen, Germany, will present an abstract titled "P. gingivalis Infection and Immune Evasion of Oral Carcinomas" at the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain
Meyle and his team are investigating the relationship of oral cancers and periodontal disease. They achieved results by infecting cell carcinoma cells SCC-25 with Porphyromonas gingivalis (P.g.) W83. After 48h the cells were stained with antibodies against human B7-H1, B7-DC and TLR4 and analysed by flow cytometry. RNA was extracted after 24h and gene expression of B7-H1, B7DC, TLR4, IFN-γ and IL-10 was quantified by real time PCR and analysed by the ΔΔCT method.
Oral Cancer | Mouth Cancer - Types, Causes, Symptoms, Diagnosis, Treatment & Prevention
Oral cancer is a cancer that develops in any part of the mouth. It is more common in men over 40.
Oral cancer is a cancer that develops in any part of the mouth. It is more common in men over 40.
P.g., a putative periodontal pathogen, is an etiologic agent of periodontitis and expresses a variety of virulence factors. In this study the expression of B7-H1 and B7-DC receptors and TLR4 on squamous cell carcinoma cells SCC-25 was analysed after infection with P.g. in vitro.
The research concludes that P.g. is able to induce the expression of the immune regulating receptors B7-H1 and B7-DC in squamous cell carcinoma which may facilitate immune evasion of oral cancers in patients with periodontal infections.
Bleeding Gums - Causes, Symptoms, Diagnosis & Treatment
Bleeding gums is a condition in which blood leaks from the gums and the spaces between the teeth. Gingivitis and periodontitis are the causes of bleeding gums which result in pain and swollen gums.
Bleeding gums is a condition in which blood leaks from the gums and the spaces between the teeth. Gingivitis and periodontitis are the causes of bleeding gums which result in pain and swollen gums.
Source-Eurekalert
About Cancer in Women
Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have evolved, rather rapidly, in the past two decades.
Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have evolved, rather rapidly, in the past two decades.
Developmental Disturbances of the Tongue
Tongue is the only muscle that is attached to only one end. The abnormalities of the tongue include tongue disease, tongue tie and size-related anomalies.
Tongue is the only muscle that is attached to only one end. The abnormalities of the tongue include tongue disease, tongue tie and size-related anomalies.
