Study says dendritic cell-specific transcript is a key regulator of nuclear receptor activity that may have prognostic value in breast cancer
A new study published online December 14 in the Journal of the National Cancer Institute says that DC-SCRIPT, or dendritic cell-specific transcript, is a key regulator of nuclear receptor activity that may have prognostic value in breast cancer.
In this study, a team led by Gosse J. Adema, Ph.D., of the Department of Tumor Immunology, at the Radboud University Nijmegen Medical Centre, the Netherlands, and colleagues assessed the role of DC-SCRIPT as a co-regulator of nuclear receptors, including estrogen receptor (ER), progesterone receptor (PR)-B, peroxisome proliferator–activated receptor gamma, and retinoic acid receptor alpha. Prognostic value was assessed in three independent cohorts of breast cancer patients.
Breast Cancer - Causes, Risks, Symptoms, Diagnosis, Staging, Treatment, Prevention & Prognosis
Breast cancer is a cancer that affects the breasts or mammary glands. Early detection and lifestyle changes help in controlling breast cancer.
Breast cancer is a cancer that affects the breasts or mammary glands. Early detection and lifestyle changes help in controlling breast cancer.
In addition, they showed that breast tumors express lower levels of DC-SCRIPT mRNA than normal breast tissue and that breast tumor cell lines do not express it.
"On the basis of these findings, we hypothesize that the antiproliferative effect of DC-SCRIPT in breast cancer cells is mediated by modulating the activity of multiple nuclear receptors," the authors write. "It will be interesting therefore to also examine DC-SCRIPT expression levels in clinical trials that have explored the effect of stimulation of the RAR/RXR and PPAR/RXR pathways on the clinical outcome in breast cancer patients."
About Cancer in Women
Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have evolved, rather rapidly, in the past two decades.
Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have evolved, rather rapidly, in the past two decades.
Source-Eurekalert
RAS
Breast Lumps
Most breast lumps are caused by hormonal changes in a woman and may not be cancerous. Common causes of breast lumps include fibroadenosis, breast cancer, breast cyst.
Most breast lumps are caused by hormonal changes in a woman and may not be cancerous. Common causes of breast lumps include fibroadenosis, breast cancer, breast cyst.
Breast Self Examination
Slides and animation of Breast Self Examination for early detection of breast cancer lumps in women
Slides and animation of Breast Self Examination for early detection of breast cancer lumps in women
