Research Defines Molecular On-off Switches for Cancer and Autoimmunity

Scientists from the Institute for Advanced Studies in New Jersey are examining how oncogenes and tumour suppressor genes handle cellular stress, and said that each of these opposing

Scientists from the Institute for Advanced Studies in New Jersey are examining how oncogenes and tumour suppressor genes handle cellular stress, and said that each of these opposing systems could be potent drug targets in the effort to stop cancer.

In addition, their hypothesis provides new insights into what contributes to immunological disorders such as chronic inflammation and autoimmune diseases.

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"Among those experiments are the synthesis of new drugs to inhibit pathways that could change the course of a disease," said Arnold Levine, Ph.D., co-author of the study from the Institute for Advanced Study in Princeton, New Jersey.

The research specifically examines the roles of the p53 tumour suppressor and the oncogene, NF-kappaB.

The p53 suppressor limits the consequences of stress by initiating cell death and promoting metabolic patterns in the cell. The oncogene NF-kappaB on the other hand, promotes cell division resulting in the synthesis of substrates for cell division.

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These two opposite cellular responses cannot function in the same cell at the same time. So Levine and colleagues speculate that drugs could be developed to take advantage of the fact that if one factor is activated, the other is rendered inactive.

"Our cells use the p53 and NF-kappaB pathways to respond to cellular stress: one controls cancer, the other immunity. If they get out of balance, we're in trouble.," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal.

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"Thanks to this work we can start restore the balance by means of new drugs."

The report is published in the October 2010 print issue of The FASEB Journal.

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Source-ANI