Fibrosis is a scarring condition that is characterized by excessive collagen production that impedes normal cell function and can cause organ dysfunction and failure.
Fibrosis is a scarring condition that is characterized by excessive collagen production that impedes normal cell function and can cause organ dysfunction and failure. Evidence from several studies suggests that connective tissue growth factor (CCN2) plays a central role in fibrotic conditions in many organ systems..
A hallmark of fibrosing injury in the liver is the activation of hepatic stellate cells (HSCs) which become highly proliferative, synthesize increased levels of transforming growth factor (TGF)-β and CCN2, and produce excessive amounts of collagen. Previous studies have not investigated the effect of CCN2 antagonism in HSCs of human origin.
Alcoholic Liver Disease - Causes Symptoms Diagnosis Treatment FAQs
Encyclopedia section of medindia gives general information about Alcoholic Liver Disease.
Encyclopedia section of medindia gives general information about Alcoholic Liver Disease.
By designing a novel antisense inhibitor that blocked CCN2 mRNA transcription and protein production, the investigators showed that in activated human HSCs, basal or TGF-β1-induced transcription and production of collagen I could be reduced, and the ability of the cells to actively divide was curtailed. The innovative features of this study involve the use of human HSCs and the delivery of the antisense molecule in the form of a hammerhead ribozyme, which has a more efficient blocking action than some other conventional antisense methods. The data show that the anti-fibrotic properties of CCN2 hammerhead ribozyme are to the result of a reduction of collagen production and cell proliferation.
The results suggest that CCN2 hammerhead ribozyme has utility as a therapeutic agent for treating hepatic fibrosis in vitro. This is important as therapy for liver fibrosis is currently lacking despite the fact that millions of individuals around the world suffer from liver fibrosis caused by hepatitis, alcohol consumption, and other types of chronic liver injury.
Liver Biopsy - Risks, Making Safe
Learn how liver biopsy is done? What are the complications of liver biopsy and what safety precautions are required before biopsy.
Learn how liver biopsy is done? What are the complications of liver biopsy and what safety precautions are required before biopsy.
Source-Eurekalert
RAS
Liver Cancer - Types, Causes, Symptoms, Diagnosis, Treatment, Prevention, Progosis
Liver or hepatic cancer is an abnormal growth of cells in the liver. The leading cause of the disease is cirrhosis or scarring of the liver tissue.
Liver or hepatic cancer is an abnormal growth of cells in the liver. The leading cause of the disease is cirrhosis or scarring of the liver tissue.
Liver Transplantation - Facts, Contraindications, Procedure, Follow up, Complications & Prognosis
Liver transplantation is a surgical option for the treatment of liver failure where the diseased liver is replaced with a healthy one.
Liver transplantation is a surgical option for the treatment of liver failure where the diseased liver is replaced with a healthy one.
