Risk Of Cancer Doubles in the Presence of Two Carcinogens

Low doses of arsenic and estrogen together- even at levels low enough to be considered safe for humans if they were on their own - can cause cancer in prostate cells, a new study

Low doses of arsenic and estrogen together- even at levels low enough to be considered "safe" for humans if they were on their own - can cause cancer in prostate cells, a new study led by an Indian-origin researcher has revealed.

According to Kamaleshwar Singh, an assistant professor at The Institute of Environmental and Human Health (TIEHH) at Texas Tech, the findings could have an impact on health regulations regarding the "safe" doses of these chemicals and others.

Cigarette Smoking - A Silent Killer-Facts, Passive Smoking & How to Quit
Smoking kills the smoker silently, pushing him towards serious illnesses, which slowly lead to death.

Singh said that unlike stronger chemicals that do major damage to the DNA in a cell, such as benzene, arsenic and estrogen aren't major mutagens.

Instead, their presence tends to stop certain genes from expressing. The process is called DNA hypermethylation.

In the experiment, human prostate cells were treated about once a week for six months with arsenic, estrogen and a combination of the two. Many of the tests involved levels of arsenic, estrogen or both at levels considered safe by the Environmental Protection Agency.

Intestinal Inflammation and Carcinogenesis may be Abetted by Bacterial Imbalance
Previous research has indicated that instability in the composition of gut bacterial communities called dysbiosis can cause common human intestinal disorders.

Singh's doctoral student, Justin Treas, said the two chemicals stopped the MLH1 gene, which is responsible for sending the signal to start the self-destruct sequence when a cell is damaged.

Because the self-destruct couldn't activate, the cells became cancerous after exposure.

Harmful Effects of Carcinogens on Cancer Stem Cells can be Reduced by Spinach
The actions of a known carcinogen in cooked meat to its complex biological effects on microRNA and cancer stem cells have been unraveled by scientists.

It was found that with the lower dose not killing the cell, it's causing damages that go under the cell's radar.

The research suggested that when you have two compounds together, lower doses could be more serious problem.

The study was published online in the peer-reviewed journal The Prostate.

Source-ANI