Risk Of Severe Malaria Reduced By 40% With Gene Variant

Malaria caused by a plasmodium parasite infects human red blood cells. A genetic rearrangement of GYPA and GYPB genes reduces the risk of severe malaria.

A gene variant related to human blood cells, that reduces the risk of severe malaria by 40 percent has been identified by researchers.

Malaria is a disease caused by a plasmodium parasite, transmitted by the bite of infected mosquitoes. Plasmodium falciparum, the most widespread malarial parasite in Africa which infects human red blood cells and gains entry via receptors on the cell surface and is also the most dangerous.

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‘People with GYPA and GYPB genes, are less likely to develop severe complications of malaria.’

More than 200 million people a year are infected with malaria and in 2015 the disease caused the deaths of nearly half a million people worldwide, revealed the research published in the Journal Science.

The study identified a genetic rearrangement of red blood cell glycophorin receptors GYPA and GYPB genes which are unusually common in Africa which confers a 40 percent reduced risk from severe malaria.

"We found some people have a complex rearrangement of GYPA and GYPB genes, forming a hybrid glycophorin, and these people are less likely to develop severe complications of the disease," said Ellen Leffler from the University of Oxford.

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Previous studies revealed that glycophorin receptors are located on the surface of red blood cells and are amongst many receptors that bind Plasmodium falciparum but were unknown to be involved in protection against malaria.

"Our discovery that a specific variant of glycophorin invasion receptors can give substantial protection against severe malaria will hopefully inspire further research on exactly how Plasmodium falciparum invade red blood cells," added lead author Dominic Kwiatkowski, Professor at the Wellcome Trust Sanger Institute and University of Oxford.

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For the study, the team investigated 5,310 individuals from the normal population and 4,579 people who were hospitalised.

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Source-IANS