There is a need to understand the role and functional consequences of exhausted T cells as they relate to impacting on the immune system and how that interplays with outcomes in cancer therapies.
Cervical Cancer - Types, Causes, Symptoms, Diagnosis, Treatment, Complications & Prevention
Cancer cervix refers to cancerous growth in the cervix and usually occurs in the transition called squamo-columnar junction.
Cancer cervix refers to cancerous growth in the cervix and usually occurs in the transition called squamo-columnar junction.
‘There is a need to understand the role and functional consequences of exhausted T cells as they relate to impacting on the immune system and how that interplays with outcomes in cancer therapies.’
A better understanding of the role secreted inflammatory cytokines play in the tumor microenvironment that results in the differentiation of effector T cells into exhausted T cells points to possible approaches to improve the antitumor activity of T cells and to intervene in T cell exhaustion. In the review article, "The Role of Inflammatory Cytokines in Creating T Cell Exhaustion in Cancer," Hedayatollah Shirzad and colleagues from Shahrekord University, Shahrekord, Iran report on multiple studies that illustrate a direct role for inflammatory cytokines in the creation of cell exhaustion through multiple pathways. The researchers recommend a greater focus on efforts to reprogram exhausted T cells in the early stages and alternatively, therapeutic interventions such as anti-inflammation therapy.
"Clearly there is room and need for further understanding of the role and functional consequences of exhausted T cells as they relate to impacting on the immune system, how that interplays with outcomes in cancer therapies, and how advantages might be taken to improve existing therapeutic strategies," says Cancer Biotherapy and RadiopharmaceuticalsEditor-in-Chief Martin W. Brechbiel, PhD.
Childhood Cancer - Types, Causes, Symptoms, Diagnosis, Complication & Prevention
Childhood or pediatric cancers occur in children less than 15 years of age. They are rare and differ from adult tumors in their location and behaviour.
Childhood or pediatric cancers occur in children less than 15 years of age. They are rare and differ from adult tumors in their location and behaviour.
Colorectal Cancer - Types, Causes, Risk Factors, Symptoms, Diagnosis, Treatment, Prognosis & Prevention
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third most common cancer in men.
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third most common cancer in men.
Salivary Gland Cancer-Causes-Types-Symptoms-Diagnosis-Treatment-FAQs
Most salivary gland tumors are benign and occur in parotid gland. The most common sign of a salivary gland tumor is a painless mass.
Most salivary gland tumors are benign and occur in parotid gland. The most common sign of a salivary gland tumor is a painless mass.
