Scientists Develop First Genetic Test for Predicting IVF Success

The first genetic blood test for predicting the chances that in vitro fertilization (IVF) will lead to a successful pregnancy has been developed by scientists.

The test is based on the finding that different subtypes of the FMR1 gene (also known as the fragile X mental retardation gene) in potential mothers are associated with significantly different chances of conceiving with IVF.

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"This is the first evidence that a specific gene appears to be directly associated with IVF outcomes," said David Barad, one of the study's senior authors.

"Our research also suggests the FMR1 gene, some forms of which are known to predict premature ovarian failure, could be used to predict at what age a woman's fertility is going to start decreasing," he said.

The study has also supported the belief that autoimmunity (immunity to one's own cells or tissues) plays a role in infertility-a controversial topic among reproductive medicine specialists.

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The study involved 339 female infertility patients who underwent a total of 455 IVF cycles at CHR. The researchers investigated the relationship between three different FMR1 genotypes and pregnancy outcomes and autoimmunity levels.

Women with the "normal" FMR1 genotype had a 38.6 percent pregnancy rate; those with the "heterozygous-normal/high" genotype had a 31.7 percent pregnancy rate; and women found to have the "heterozygous-normal/low" genotype had a 22.2 percent pregnancy rate.

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The genotype associated with the lowest pregnancy rate was also associated with increased measures of autoimmunity.

Women with this genotype also had a higher incidence of polycystic ovary syndrome (a common cause of infertility), which is thought to have an autoimmune component.

"Previous studies have suggested that autoimmunity plays a role in infertility. Now, for the first time, we have a potential genetic mechanism that underlies several different threats to infertility," said Barad.

The cost of the blood test for the FMR1 should be relatively low - comparable to screening tests for Tay-Sachs and other genetic diseases.

"Any test that is proven to have predictive value for a woman's fertility would give her a heads up in terms of planning a family," he added.

The findings were reported in the online medical journal PLoS One.

Source-ANI