A new candidate tumor suppressor gene in colorectal cancer and examined its use as a potential biomarker in stool samples has been identified
A new candidate tumor suppressor gene in colorectal cancer and examined its use as a potential biomarker in stool samples has been identified, a new study published online June 17 in the Journal of the National Cancer Institute has revealed.
In the study, Manon van Engeland, Ph.D., of the Department of Pathology at Maastricht University Medical Center in the Netherlands, and colleagues examined N-Myc downstream-regulated gene 4 (NDRG4) as a novel tumor suppressor and biomarker.
Colorectal Cancer - Types, Causes, Risk Factors, Symptoms, Diagnosis, Treatment, Prognosis & Prevention
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third most common cancer in men.
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third most common cancer in men.
The researchers found that NDRG4 promoter methylation was more prevalent in colorectal cancers than in noncancerous colon mucosa. Its mRNA and protein expression were decreased in colorectal cancer tissue compared with noncancerous colon mucosa. A methylation-specific polymerase chain reaction assay for NDRG4 promoter methylation in stool identified the presence of colorectal cancer in 53% of colorectal cancer cases and correctly categorized a subject as cancer free 100% of the time.
"In conclusion, to our knowledge, this is the first study to describe a tumor suppressor role for NDRG4 in cancer," the authors write. "Our data indicate that NDRG4 promoter methylation is potentially useful as a sensitive and specific noninvasive pre-selection modality for identifying individuals at risk for colorectal cancer for whom colonoscopy is recommended."
Colo-rectal Cancer - Management
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological therapy. Some people require a combination of treatments.
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological therapy. Some people require a combination of treatments.
"Genetic diagnosis of colorectal cancers and meaningful adenomas has now reached a new phase that, when further fine-tuned, may carry the promise of becoming a suitable and affordable means of prevention and early detection of colorectal cancer in the general population," he writes.
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Colonoscopy Procedure
An animation of Colonoscopy that shows the appearance of large intestine or colon by using a thin and flexible viewing tube called the colonoscope.
An animation of Colonoscopy that shows the appearance of large intestine or colon by using a thin and flexible viewing tube called the colonoscope.
Source-Eurekalert
RAS
Volvulus
A volvulus is surgical condition that results in a loop of the bowel twisting on itself. This can be a life-threatening condition due to the loss of blood supply and accumulation of toxic gases and fluids in the portion of the obstructed bowel segment.
A volvulus is surgical condition that results in a loop of the bowel twisting on itself. This can be a life-threatening condition due to the loss of blood supply and accumulation of toxic gases and fluids in the portion of the obstructed bowel segment.
