Scientists Identify New Target in War on Malaria

A new target in the parasite that causes malaria has been identified by scientists.

A new target in the parasite that causes malaria has been identified by scientists. Malaria is a disease that causes more than a half a million deaths annually.

Potential drugs can aim at a newly-discovered enzyme that the parasite uses to metabolise energy at every stage of its infection in humans, they said.

Malaria - Causes, Symptoms, Diagnosis, Prevention, Treatment
Malaria is caused by a parasite that enters blood through the bite of an infected mosquito. It is characterized by fever, vomiting, shivering, sweating and other symptoms.

The finding, published in the journal Nature, is important because only a tiny handful of weaknesses have been found that apply to every stage of the complex process by which the Plasmodium parasite grows and multiplies in the body.

Most drugs aim at specific stages in the parasite's cycle, not all.

They notably fail to wipe out early forms of the parasite called hypnozoites that remain dormant in the liver and then revive, triggering a malarial relapse.

About Mosquito Diseases
Mosquito-borne diseases, like malaria, filaria, dengue, etc are common in places conducive of mosquito breeding. Swamps, ponds and stagnated drainage provide optimal breeding ground for mosquitoes.

The new target, called phosphatidylinositol-4-kinase, or PI4K, is an enzyme that the parasite needs to survive in host cells.

"Most drugs selectively work on certain stages of the (parasite's) life cycle, but not all stages," said Case McNamara, a genomics specialist at the Novartis Research Foundation in San Diego, California.

Fever / Pyrexia - Symptom Evaluation - Types - FAQs
Fever or Pyrexia is an elevation in normal body temperature. Causes of fever include infections, injury, cancers, inflammation, hormonal, metabolic and genetic diseases.

"Inhibitors of this drug target have the potential to not only cure individuals of a malaria infection, but also to prevent infections and even block transmission of the parasite back to the mosquito."

The only drug that is currently licensed to wipe hypnozoites is primaquine.

Licensed more than half a century ago, the formula is considered a last-throw-of-the-dice option, as it can cause potentially life-threatening anaemia for people with an inherited genetic mutation.

According to the UN's World Health Organisation (WHO), 219 million people became infected with malaria in 2010, of whom 660,000 died, most of them African children under the age of five.

Source-AFP