A protein called ABCB5 in colorectal cancers that increases treatment resistance and recurrence of the tumour has been identified by scientists at the Children's Hospital Boston.
Colorectal Cancer - Types, Causes, Risk Factors, Symptoms, Diagnosis, Treatment, Prognosis & Prevention
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third most common cancer in men.
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third most common cancer in men.
To understand ABCB5's role in treatment resistance, the team examined biopsies gathered from colorectal cancer patients both before and after treatment with 5-fluorouracil (5-FU), a standard chemotherapeutic for this tumor.
They found that the percentage of cells expressing ABCB5 increased more than fivefold after treatment.
Colo-rectal Cancer - Management
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological therapy. Some people require a combination of treatments.
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological therapy. Some people require a combination of treatments.
Knocking down ABCB5 expression both blocked the growth of these cells and restored their sensitivity to the drug, showing that ABCB5 is not only a marker of treatment resistance but actually drives it.
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Colonoscopy Procedure
An animation of Colonoscopy that shows the appearance of large intestine or colon by using a thin and flexible viewing tube called the colonoscope.
An animation of Colonoscopy that shows the appearance of large intestine or colon by using a thin and flexible viewing tube called the colonoscope.
Source-ANI
