Scientists Identify Protein That Could be New Target to Reduce Damage After Heart Attack

A protein that plays a key role in debilitating changes that occur in the heart after a heart attack has been identified by scientists.

These changes, or 'remodelling' of the heart, often lead to fatal heart failure.

What is a heart attack / How to prevent heart attacks
Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to avoid heart attack are listed.

Researchers found that mice genetically altered to lack fibronectin-EDA (FN-EDA) had less heart damage after a heart attack.

The findings hold potential for therapies to reduce or prevent heart muscle damage after a heart attack.

Researchers compared the effect of heart attacks in two groups of mice.

One group was genetically engineered to lack fibronectin-EDA (FN-EDA), a protein that exists in the space surrounding cells and is important for processes such as cell migration and wound healing. The other mice were genetically normal.

After inducing a heart attack in the left coronary artery of each mouse, the team found that the hearts of mice lacking FN-EDA had less enlargement in the left ventricle, better pumping ability and less thickening of the heart muscle) compared to the control mice.

Heart Attack - Overview
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the leading cause of death in the United States. Other names for heart attack include acute myocardial infarction, coronary thrombosis, and coronary occlusion.

At the tissue level, the genetically engineered mice also had less inflammation; diminished activity of the enzymes metalloproteinase 2 and 9, which are involved in heart remodelling; and reduced myofibroblast transdifferentiation (a process in which cells near an injury site transform into myofibroblasts, which are cells that help heal injured tissue).

Bone marrow transplantation experiments revealed that the FN-EDA involved in the remodelling process came from the heart and not from cells circulating in the bloodstream.

Congenital Heart Disease – Septal Defects
Heart diseases that are present at birth are called “ Congenital heart diseases”.

The study appears in Circulation Research.

Source-ANI