Communication through CCR4 may be one mechanism that cancer cells use to create a pro-tumor environment that protects tumors from immune system attacks.
Bone Cancer in Children and Adolescents Shows Epigenetic Diversity
Ewing sarcoma tumors carry very few DNA mutations that could explain the observed differences in the disease course of Ewing sarcoma patients.
Ewing sarcoma tumors carry very few DNA mutations that could explain the observed differences in the disease course of Ewing sarcoma patients.
‘Communication through CCR4 may be one mechanism that cancer cells use to create a pro-tumor environment that protects tumors from immune system attacks.’
Antibodies that block CCR4 are currently in clinical trials for treating blood and lymphatic cancers, but these approaches may also effectively target cancers that produce solid tumors. In this issue of the JCI, a study led by Frances Balkwill at Barts Cancer Institute evaluated whether blocking CCR4 in a mouse model of cancer could counteract the signaling that creates a pro-tumor environment.
In mice with renal cell carcinoma, antibody-mediated inhibition of CCR4 changed the composition of immune cell populations that were present in the tumor microenvironment. The changes were associated with reduced tumor proliferation, suggesting that inhibition of CCR4 had anti-tumor effects.
Delays in Access to Cancer Medicines and Unjustifiable Price Rises Disadvantage Patients
There is no value for patients if new cancer drugs are developed and approved but they are unable to benefit from them.
There is no value for patients if new cancer drugs are developed and approved but they are unable to benefit from them.
Source-Eurekalert
Some Breast Cancer Patients Benefit More from Breast Conservation Therapy
Equal survival outcomes for BCT and mastectomy, trials often exclude elderly patients or patients with existing disease other than breast cancer (comorbidity).
Equal survival outcomes for BCT and mastectomy, trials often exclude elderly patients or patients with existing disease other than breast cancer (comorbidity).
How Protein Production Gets Distorted in Skin Cancer
Each cell in the body follows a strict protocol for manufacturing the proteins it needs to function.
Each cell in the body follows a strict protocol for manufacturing the proteins it needs to function.
