Simple Blood Test Can Predict Immunotherapy Efficacy in Bladder Cancer Patients

Simple blood test can help identify bladder cancer patients who may not benefit from immunotherapy.

Simple blood test can help identify bladder cancer patients who may not respond to immunotherapy, reports a new study.

This could potentially save months of unnecessary and ineffective treatment.

Bladder Cancer – Symptoms, Signs, Diagnosis, Treatment, Prognosis & Prevention
Bladder cancer occurs due to abnormal cell growth in the urinary bladder. The most common kind usually is urothelial cancer or transitional cell carcinoma.

‘Simple blood test can identify patients who are unlikely to benefit from a commonly used immunotherapy for bladder cancer.’

Currently, 30-40% of individuals have no benefit from the standard immunotherapy treatment, and they are only identified once therapy has failed, which often takes six months or longer to find out.

The pilot study, conducted under the supervision of Professor Florian Kern, Chair of Immunology at BSMS, shows that a test measuring the release of the pro-inflammatory molecule, Interleukin-2, from immune cells performed before therapy appears to immediately identify about 50% of the patients who will not benefit from the treatment.

Overall, the test correctly predicted therapy outcome in almost 80% of cases.

Urine Test Helps Detect Bladder Cancer Recurrence
The presence of Telomerase reverse transcriptase in the urine helps predict recurrence of bladder cancer in more than 80% of patients.

Bladder cancer is among the top most common cancers worldwide and predominantly affects older men, with hundreds of thousands of cases every year.

The majority present with early bladder cancer that has not yet infiltrated the muscular layer of the bladder, and this is treated by removing the tumor.

Bladder Cancer: Robotic Surgery is as Effective as Traditional Surgery
When robotic and traditional surgery of bladder cancer were compared, it was found that both these methods were equally effective and no major risk to the patients was found after the surgery.

Subsequent instillation of live bacteria, Bacille Calmette-Guérin(BCG), which is also used in tuberculosis (TB) vaccine, given in several cycles over one year, reduces the otherwise high recurrence and progression rates.

This report suggests that the immune response to Tuberculin, widely used in TB testing, may help identify those who will benefit or not from BCG immunotherapy.

New Strategy for Treating Bladder Cancers
Arginine-degrading-enzyme therapy is beneficial for the treatment of cancers lacking the enzyme needed for arginine synthesis (argininosuccinate synthetase 1).

The lead author, Dr. Samer Jallad, Urologist previously at Brighton and Sussex University HospitalsTrust, now working at Imperial College Healthcare NHS Trust, London said: "Our results suggest that a test predicting the outcome of BCG immunotherapy may be within reach. This would be extremely useful for making the best choices for our patients and using alternative treatments for those who are unlikely to benefit. If confirmed in a larger study, this test could save tens of thousands of patients valuable time and the negative experience of undergoing eventually unsuccessful therapy."

Professor Kern added: "The simplicity of our new test makes it very attractive as a clinical test. There are several tests for tuberculosis that are ultimately based on the same test principle and have been rolled out across the world in recent times."

Source-Eurekalert