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Stem Cell Treatment Resolves Perianal Fistulas in Crohn’s Disease

by Dr. Jayashree Gopinath on Mar 6 2023 11:42 PM
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Can stem cell therapy cure fistula? Yes, treatment with stem cells has had a success rate when used in perianal fistulas due to Crohn’s Disease.

 Stem Cell Treatment Resolves Perianal Fistulas in Crohn’s Disease
A dissolvable plug delivered stem cell therapy with few side effects in patients with single tract perianal fistulas, researchers have discovered and published in the journal Diseases of the Colon & Rectum.
Perianal fistulas are painful tunnels between the intestine and the skin that often do not go away with standard medical or surgical care. People with Crohn's disease or other inflammatory bowel conditions are most at risk for this condition.

Researchers loaded stem cells from a patient's fat tissue onto a bioabsorbable plug that was then surgically implanted to close the anal fistula tract. They followed the patients for one year and reported the results of their early research.

As many as 26% of people with Crohn's disease will develop perianal fistulas. Most often, it starts with an infection within the anal gland and often progresses into an abscess that sometimes requires surgery.

Left untreated, perianal fistulas leak fecal material and can lead to permanent colostomy and, in some cases, cancer. A colostomy is a surgical opening in the abdomen that bypasses the damaged colon to rid the body of solid waste. Perianal fistulas can cause quality-of-life challenges, such as the need to wear pads to protect clothing and prevent odor.

Perianal fistulas are a complex medical condition that even when repaired surgically, can reoccur, causing a lot of suffering for patients. The research team extracted mesenchymal stem cells from the adipose (fat) tissue of 20 patients with perianal fistulas who had not responded to standard medical or surgical treatment.

Stem Cell Therapy: A Crohn's Disease Breakthrough in 2023?

Mesenchymal stem cells are adult stem cells with healing potential that have been well studied. After multiplying the stem cells in the lab, the team combined the cells with a plug created from a dissolvable material.

They surgically implanted the plug to close the anal fistula tract and then monitored the patients seven times within 12 months, with a focus on investigating safety. They also studied whether the treatment intervention led to clinical healing that could be confirmed through deep-tissue imaging.

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Later, documented complete healing of 14 patients at six months and 13 patients at one year. Three patients withdrew for various reasons during the clinical trial. Four participants reported side effects such as infections that required admission to the hospital or surgical draining of an abscess. Twelve participants experienced reactions considered to be minor, such as redness, fever, or nausea.

Based on their findings, it is recommended to continue further study of the stem cell-coated fistula plug with larger sample sizes and more types of fistulas. If all goes well, it could take two or three years before this procedure is approved for routine clinical care.

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Source-Eurekalert


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