Stress related pathway inside the ER was found to be instrumental in controlling the function of natural killer T cells, stated new study.
�Super Natural Killer Cells� Destroy Cancer In Lymph Nodes
Injecting liposomes armed with TRAIL (Tumor necrosis factor Related Apoptosis-Inducing Ligand) that attach to natural killer cells in the lymph nodes destroyed cancer cells.
Injecting liposomes armed with TRAIL (Tumor necrosis factor Related Apoptosis-Inducing Ligand) that attach to natural killer cells in the lymph nodes destroyed cancer cells.
‘Natural killer T cells form a specialized immune cell that protects against a variety of diseases such as cancer, autoimmunity, metabolic disease or certain infections such as Lyme disease. This is because of their ability to make very rapidly large amounts of cytokines, which act as major communicators between different cell types.’
Why natural killer T cells are able to make these molecules so abundantly was unclear. This seems to deviate from other immune cells which underscores the selectivity of this mechanism to this particular cell type. Prof. Dirk Elewaut (VIB-UGent): "The identification of this stress related response opens new avenues. We believe that the modulation of this response could lead to novel strategies to control diseases mediated by natural killer T cells."
Source-Eurekalert
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