Study Examines Effect of the Flu-causing Virus, Influenza A

New study suggests that the influenza virus may hijack autophagosomes, perhaps using the compartments for viral protein translation.

New study conducted by scientists has detected an increase in viral and ribosomal proteins in the autophagosome, which they linked to a reduction in successful autophagy.

Meanwhile, a smaller group of people is making a more focused attempt to learn about lots of flu proteins. Andrea C. Becker at the University of Freiburg and her colleagues in Germany and Switzerland investigated the effect of the flu-causing virus, influenza A, on three lung-derived cell lines and published their results in the journal Molecular & Cellular Proteomics.

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‘Inspired by the annual 3 to 5 million cases of severe influenza worldwide, the Guinness World Record organization is advertising for individuals or organizations to attempt a record for the most people getting a flu awareness lesson at once.’

The study quantified virus-induced changes in protein levels and found that a majority of the changes are cell-line specific. More specifically, they quantified the protein levels of 70 percent of the roughly 7,000 proteins they could detect using a mass spectrometry-based isotope labeling approach known as SILAC. Influenza infection of lung cells changed the overall abundance of only a few proteins, mostly related to immunity, but SILAC comparisons showed that the virus changes the cellular location of many proteins.

Source-Eurekalert

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Influenza (or rather, the flu) is a cold weather infectious condition that affects the young and old alike. Though most reported cases are mild, the flu can sometimes cause severe and life-threatening complications in both children and adults, thanks to wrong medications and improper vaccinations. Learn more about the disease from our Flu Quiz and guard yourself and your family from a possible infection.

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