Study Finds Invisible Gut Inflammation in Psoriasis Patients

People with psoriasis often have gastrointestinal problems and are more prone to developing Crohn’s disease. A new study finds psoriasis patients have an invisible inflammation in the small intestine that can lead to a ‘leaky gut’. The study is published in Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease (1^✔ ✔Trusted Source
Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier

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Psoriasis is a hereditary, chronic skin condition that can also cause inflammation of the joints. About 300,000 people in Sweden live with psoriasis. Chronic inflammatory bowel disease (IBD) and Crohn’s disease are more common in them.

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Hidden Gut Inflammation in Psoriasis

“Previous research has also shown that people with psoriasis have more gastrointestinal problems than the general population. However, we didn’t know much about why this was the case. With our study, we can now show that people with psoriasis often have invisible inflammation in their small intestines, with an increased risk of what’s called leaky gut,” says Maria Lampinen, a researcher at Uppsala University.

The study involved 18 patients with psoriasis and 15 healthy controls as subjects. None of the participants had been diagnosed with gastrointestinal diseases. Samples were taken from both their small and large bowls. The researchers then studied different types of immune cells in the mucous membrane.

“It turned out that psoriasis sufferers had higher numbers of certain types of immune cells in their small intestine, and the cells showed signs of pro-inflammatory activity. Interestingly, we found the same type of immune cells in skin flare-ups from psoriasis patients, suggesting that the inflammation of the skin may have an impact on the gut, or vice versa.

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Leaky Gut: Its Role in Psoriasis

Normally, the intestinal mucosa acts as a protective barrier that also allows nutrients and water to pass through it. In some autoimmune diseases, the intestinal barrier may function poorly. This is called having a leaky gut and leads to bacteria and harmful substances leaking through the intestinal barrier and causing inflammation. This can also cause more widespread inflammation when these substances are spread via the bloodstream.

Half of the psoriasis patients in the study had increased intestinal barrier permeability or leaky gut. These same patients also reported more gastrointestinal symptoms such as abdominal pain and bloating than patients with a normal intestinal barrier. They also had elevated levels of inflammatory substances in their intestines.

“Given that the psoriasis patients in our study had a relatively mild skin disease and showed no visible intestinal inflammation in a gastroscopy, they had surprisingly clear changes in their small intestine compared to healthy controls. These changes could explain why psoriasis sufferers often have gastrointestinal problems, and an increased risk of developing Crohn’s disease.

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Gut-Skin Link in Psoriasis

The Psoriasisförbundet (the Swedish Psoriasis Association) member magazine published an article about this study. Following its publication, Maria Lampinen received many e-mails from people who recognized this phenomenon.

“They wanted to know more about the link between the gut and the skin because they recognized that their gut and skin symptoms were often linked. So it feels like this research is needed and is important for the patients themselves. A greater understanding of gastrointestinal problems in psoriasis patients can help the healthcare system pay more attention to the link between the gut and the skin in patients with psoriasis, and in the long term, it could also lead to better treatment of these problems.

Reference:

1. Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier - (https://www.sciencedirect.com/science/article/pii/S0925443924006288?via%3Dihub)

Source-Eurekalert