Study Finds Link Between Absence of Key Enzyme in Folic Acid Metabolism and Birth Defects

The risk of neural tube birth defects in a developing embryo increases in the absence of a critical enzyme in the folic acid metabolic pathway, according to a new study.

The risk of neural tube birth defects in a developing embryo increases in the absence of a critical enzyme in the folic acid metabolic pathway, according to a new study conducted by researchers at University of Texas.

It has been known for several decades that folic acid supplementation dramatically reduces the incidence of neural tube defects, such as spina bifida and anencephaly, which are among the most common birth defects. In some populations, folic acid supplementation has decreased neural tube defects by as much as 70 percent.

About Multifactorial Birth Defects
Encyclopedia section of medindia gives in brief General Info about About Multifactorial Birth Defects.

However, scientists still do not fully understand how folic acid decreases neural tube defects, or why folic acid supplementation does not eliminate birth defects in all pregnancies.

"Now, we've found that mutation of a key folic acid enzyme causes neural tube defects in mice," said Dean Appling, professor of biochemistry in the College of Natural Sciences. "This is the clearest mechanistic link yet between folic acid and birth defects."

Appling and his colleagues published their research in the Jan. 8 issue of Proceedings of the National Academy of Sciences (PNAS).

Drug-Induced Birth Defects - Teratogenic Drugs - Causes - Effects - FAQs
Birth defects are abnormalities of function, structure or metabolism that are present since birth. Taking certain drugs during pregnancy can cause birth defects.

The scientists made the discovery using mice that lack a gene for a folic acid enzyme called Mthfd1l, which is required for cells to produce a metabolite called formate. Embryos need formate to develop normally.

"This work reveals that one of the ways that folic acid prevents birth defects is by ensuring the production of formate in the developing embryo," said Appling, "and it may explain those 30 percent of neural tube defects that cannot be prevented by folic acid supplementation."

Environmental Birth Defects - Chemical Factors - Biological Sources - Diagnosis - Treatment - FAQs
Birth defects caused due to environmental teratogens like drugs, microorganisms or exposure to radiation are called as environmental birth defects.

Appling said that the mice provide researchers with a strong model system that they can use to further understand folic acid and its role in birth defects in humans. In fact, humans share the same gene for the folic acid enzyme with the mouse and all other mammals. Indeed, it has recently been discovered that point mutations in that human gene increase the risk of birth defects.

Appling said that he and his colleagues would like to use the mouse system to begin looking for nutrients that could be delivered to pregnant mothers to prevent those neural tube defects that cannot be prevented by folic acid.

Birth Defects - Genetic - Achondroplasia
Achondroplasia is a genetic disorder which is one of the leading causes of dwarfism

Ultimately, women could someday be screened for the gene that produces the enzyme. If they are deficient, steps could be taken to improve their chances for developing embryos free of neural tube defects through further nutrient supplementation.

Folic acid was discovered at The University of Texas at Austin in the 1940s by biochemists Esmond Snell and Herschel Mitchell. The U.S. has fortified all enriched cereal grain products with folic acid since 1996 to ensure that women of childbearing age receive adequate quantities of the vitamin.

Source-Eurekalert