Study Highlights Appetite Regulation Pathway, New Hope for Weight Loss

Researchers have now identified a signaling pathway in the brain, which has been found a crucial role in regulating food intake.

Researchers have now identified a signaling pathway in the brain, which has been found a crucial role in regulating food intake. Furthermore, this pathway linked to the development of diabetes and cancer could pave way for novel weight loss methods in obese individuals.

Scientists from UC's Genome Research Institute demonstrated that the signaling pathway mTOR--activated by nutrient and hormonal signals--plays a role in the brain's ability to sense how much energy the body has available.

This finding, the researchers say, suggests that very specific micronutrients may drive these pathways in the brain and could lead to a more scientific approach to diet design to help regulate body weight.

The study, led by Randy Seeley, PhD, professor in UC's psychiatry department, appears in the May 12, 2006 issue of the journal Science.

Ingesting calories (energy in the form of nutrients) has two purposes, says Dr. Seeley.

‘We take in calories to maintain levels of stored fuel (energy) and adequate available fuel,’ he says. ‘The signals that tell our brain about both the stored and the available energy in our body can activate the mTOR pathway in key parts of the brain that control appetite.’

Knowing that mTOR basically serves as a ‘check-point’ for sensing energy changes, the researchers predicted that it could be manipulated to alter food intake.

The mTOR pathway is very sensitive to ‘branched-chain’ amino acids, particularly leucine, Dr. Seeley explains. In laboratory studies, he and his team found that when they administered leucine directly to the hypothalamus, a brain region that controls a number of metabolic processes, animals ate less.

Other, similar amino acids did not give the same results.

This animal study, says Dr. Seeley, could eventually have implications for human obesity.

‘Rather than basing our diets only on macronutrients like fat or carbohydrates, we might one day be designing diets based on micronutrients like amino acids,’ he says.

But, Dr. Seeley adds, that certainly doesn't mean people should ‘run out and add more leucine to their diets.’

‘We still have a lot to learn about how these nutrients would act if simply ingested with other nutrients, in what form they could be most effective, and even if they are effective at all when not administered directly to the brain,’ he says.