Scientists have unraveled the structures of human ABCB11 under various taurocholate (TC) bile acid concentrations and revealed a pocket-to-pocket bile acid transfer mechanism.
How Parenteral Lipid Emulsions Prevent Liver Disease in Preterm Babies?
New study explains how multi-component lipid emulsions, rather than soy-oil emulsions, prevent cholestasis.
New study explains how multi-component lipid emulsions, rather than soy-oil emulsions, prevent cholestasis.
‘Bile acid is useful in digesting lipids and vitamins. However, there can be too much of a good thing: excessive bile acid may upset metabolism or even cause cancer.’
The results were published in Cell Research. Researchers discovered two tandem binding sites in ABCB11 that were located in the outer membrane leaflet (OML) and inner membrane leaflet (IML) respectively. The OML pocket and IML pocket have different substrate affinities, and this affinity gradient made ABCB11 a “one-way street” for substrates, enabling the export of bile acid.
The two-pocket structure allowed for more precise recognition of bile acid. Researchers found that the IML pocket had two positively charge residues that served to recognize taurine moiety of bile acid. The OML pocket, on the other hand, served to recognize the cholic acid moiety and the shape of bile acid.
Recommended Treatment for Common Pregnancy Liver Disorder, Not Effective
The current drug ‘urso’, recommended for the treatment of pregnancy-related liver disorders such as the intrahepatic cholestasis of pregnancy (ICP) is ineffective.
The current drug ‘urso’, recommended for the treatment of pregnancy-related liver disorders such as the intrahepatic cholestasis of pregnancy (ICP) is ineffective.
Source-Eurekalert
Shire Receives Breakthrough Therapy Designation for Rare Diseases Drugs
The biotechnology company has tested its two drugs namely budesonide and maralixibat against two rare diseases in the phase-II trial.
The biotechnology company has tested its two drugs namely budesonide and maralixibat against two rare diseases in the phase-II trial.
Quiz on Liver
How many of us know that the liver is a vital organ the size of an American Football? To understand more about the liver and its functions spend a few minutes taking part in this quiz.
How many of us know that the liver is a vital organ the size of an American Football? To understand more about the liver and its functions spend a few minutes taking part in this quiz.
