Studying Damage to the Prefrontal Lobe Helps Unlock the Brain's Mysteries

Lobotomies were frequently used in early 20th century to treat psychiatric disorders as the frontal lobes of the brain were shrouded in mystery and erroneously thought of as nonessential for normal function. Now a review publishing August 28 in the Cell Press journal Neuron highlights groundbreaking studies of patients with brain damage that reveal how distinct areas of the frontal lobes are critical for a person's ability to learn, multitask, control their emotions, socialize, and make real-life decisions. The findings have helped experts rehabilitate patients experiencing damage to this region of the brain. Although fairly common, damage to the prefrontal lobes (also called the prefrontal cortex) is often overlooked and undiagnosed because patients do not manifest obvious deficits. For example, patients with prefrontal brain damage do not lose any of their senses and often have preserved motor and language abilities, but they may manifest social abnormalities or difficulties with high-level planning in everyday life situations.

"In this review, we aimed to highlight a blend of new studies using cutting edge research techniques to investigate brain damage, but also to relate these new studies to original studies, some of which were published more than a century ago," said lead author Dr. Sara Szczepanski, of the University of California, Berkeley. "There is currently a large push to better understand the functions of the prefrontal cortex, and we believe that our review will make an important contribution to this understanding."

Source-Eurekalert