Swings in blood glucose level, an enhancer of reactive oxygen species production increased when subcutaneous insulin infusion was done in mice.
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‘Continuous administration of insulin subcutaneously, rapidly decreased oxidative stress in liver and plasma, but failed after longer diabetes status.’
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Sigrist and colleagues at the European Center of Diabetes Study (CEED, Strasbourg, France) have reported in the January 2016 issue of Experimental Biology and Medicine that, in a diabetic rat model, a rapid increase of hepatic oxidative stress and inflammation biomarkers were observed, which is associated with drastic decrease of glycogen storage and protein synthesis. 
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Continuous administration of insulin subcutaneously, using an osmotic mini-pump (CSII), rapidly decreased oxidative stress in liver and plasma, but failed after longer diabetes status. Moreover, hepatic and systemic inflammation was not prevented and a high variability of glycogen content was observed.
In fact, CSII was not able to preserve the balance of anti- and pro-oxidant species. "Favoring a more physiological pathway for insulin administration would be a real advantage for better glycemic control, preserving organs from glucotoxicity-induced disorders and oxidative stress" stated Stéphanie DAL. These data support, for the first time, that targeting oxidative stress and inflammation could be a new therapeutic approach since conventional insulin therapy does not allow protection of the liver from chronic diabetes effects.
Dr Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "Dal et al have demonstrated the need for consideration of combining insulin with therapeutics directed towards inflammation and oxidative stress for diabetics".
Source-Eurekalert