Sugar Stops the Spread of Mosquito-Borne Arboviral Diseases

Mosquitoes feeding on sugar before they feast on a blood meal can protect their ability to get infected and transmit mosquito-borne arboviral diseases like Zika, dengue and chikungunya, reveals a new study.

The finding, published in the //journal PLOS Pathogens, could lead to the development and application of vector control strategies such as sugar baits, aimed at reducing arbovirus transmission.

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‘Lack of sugar intake can increase the spread of mosquito-borne arboviral disease. Better understanding can lead to the development and application of vector control strategies such as sugar baits, aimed at reducing arbovirus transmission.’

The research -- led by the MRC-University of Glasgow Centre for Virus Research -- showed that the Aedes aegypti species of mosquito, an arbovirus vector, had enhanced immunity in the gut after feeding on sugar, which in turn protected females of the species against viral infection.

"This study is important because we've been able to show that sugar feeding by these mosquitos blocks an initial infection of an arbovirus and lowers infection prevalence and intensity, thereby decreasing the potential of female mosquitoes to transmit these viruses further," said Dr Emilie Pondeville, Molecular Entomologist at the MRC-University of Glasgow Centre for Virus Research.

"Overall, our findings uncover a crucial role of sugar feeding in mosquito antiviral immunity, which in turn decreases the potential for spread of these arboviruses, which pose a significant threat to people," Pondeville said.

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Male and female adult mosquitoes feed on plant nectar and sap to get carbohydrates for their energy reserves. In addition, mosquito females require a blood meal to reproduce.

For this reason they can act as vectors of numerous pathogens, such as the arboviruses like Zika, dengue and chikungunya viruses, which constitute a substantial worldwide public health burden. However, the influence of sugar on mosquito immunity and their ability to transmit viruses has not been explored until now.

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Since Aedes aegypti female mosquitoes almost exclusively feed on blood in some natural settings, the findings suggest that a lack of sugar intake could increase the spread of mosquito-borne arboviral diseases; and highlights a possible explanation for high susceptibility and transmission of arboviruses by this mosquito species.

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Source-IANS