Besides proper diet and exercise, the best treatment for diabetes is the delivery of insulin into the body that is both controllable and sustainable over time.
Diabetes Insipidus - Causes, Symptoms, Diagnosis, Treatment, Complications
Diabetes insipidus (DI) is a rare condition where the kidneys cannot retain the appropriate quantity of water.
Diabetes insipidus (DI) is a rare condition where the kidneys cannot retain the appropriate quantity of water.
‘Research teams have been experimenting with polyethylene glycol (PEG) modification (PEGylation) of protein drugs to improve the stability and lifetime of insulin.’
Working toward the
development of a better insulin delivery system, a research group from
Kumamoto University in Japan has been experimenting with polyethylene
glycol (PEG) modification (PEGylation) of protein drugs through a
host-guest interaction between cyclodextrin (CyD) and adamantane to
improve the stability and lifetime of insulin, calling the results of
their work "SPRA technology". Their current research focuses on combining SPRA technology with another development of their own that allows for better control of insulin release, "polypseudorotaxane (PPRX) technology". Their goal in combining the two technologies was to develop a sustained and controllable insulin release system.
Using mono- or multi-SPRA-insulin solutions and alpha- or gamma-cylodextrin (CyD), the researchers developed four types of SPRA-insulin/CyD PPRXs, mono-SPRA-insulin/alpha-CyD, mono-SPRA-insulin/gamma-CyD, multi-SPRA-insulin/alpha-CyD, and multi-SPRA-insulin/gamma-CyD PPRX. Alpha-CyDs were found to form PPRXs with a single PEG molecule of SPRA-insulin, whereas gamma-CyD formed them with two molecules. The multi-SPRA-insulin was expected to remain in the blood supply for a relatively long period of time, and the use of different concentrations of CyDs allowed researchers to control insulin release through the CyD and PEG equilibrium reaction.
Diabetes Type 1, Type 2 - Causes Symptoms Diagnosis and Treatment FAQs
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, symptoms, diagnosis, treatment, facts and a glossary on diabetes.
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, symptoms, diagnosis, treatment, facts and a glossary on diabetes.
"We found that 232 mg/ml gamma-CyD PPRX provided for a longer blood glucose reduction time than the 116 mg/ml PPRX and the control. This is quite important since it shows that both sustained and controlled insulin release can be achieved, which is necessary for the treatment of diabetes," said lead researcher Dr. Hidetoshi Arima. "Furthermore, a blood chemistry safety analysis of creatinine, blood urea nitrogen, aspartate aminotransferase, and alanine aminotransferase were found to be unchanged by the insulin injections. Our SPRA-PPRX injections appear to be a safe and reliable insulin release system."
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Diabetes Type 2 and Its Link to Sugar-Sweetened Beverages
Sugar-sweetened beverages contribute to metabolic syndrome leading to higher risk for type-2 diabetes and cardiovascular disease.
Sugar-sweetened beverages contribute to metabolic syndrome leading to higher risk for type-2 diabetes and cardiovascular disease.
In future work, the researchers plan to combine other forms of insulin with gamma-CyD PPRX with the hope of further improving diabetes treatment. The current findings be found online in the journal Carbohydrate Polymers at ScienceDirect.com.
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Diabetic Diet - Diabetes Mellitus
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nutrients, but low in fat (especially saturated fat) and moderate in calories.
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nutrients, but low in fat (especially saturated fat) and moderate in calories.
