Researchers have identified the three dimensional structure of apolipoprotein which is responsible for cardiovascular and Alzheimer’s disease
Researchers from Gladstone Institute of Cardiovascular Disease have for the first time created the three dimensional structure of apolipoprotein E using X-ray crystallography. X-ray crystallography technique is used for determining three dimensional structures so molecules by determining the x-ray diffraction patterns of the crystals present in molecules. Researchers feel that this new discovery will help a lot in understanding the mechanism of action and ways to inhibit the action of apolipoprotein E which is found to be associated with cardiovascular and Alzheimer’s disease.
Apolipoprotein E4 (apoE4) is a lipid transporting protein which is found to be responsible for cardiovascular diseases and familial alzheimer’s disease. Researchers feel that understanding the three dimensional configuration would help in designing a drug which specifically fits on the configuration of the protein, these findings would bring new insights in to treatment of cardiovascular and alzheimer’s disease.
