Excessive vitamin A consumption may reduce bone thickness and increase the risk of bone fractures, reveals a new study.
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‘Consuming too much vitamin A may reduce bone thickness and increase the risk of bone fractures.’
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Vitamin A is an essential vitamin that is important for numerous biological processes including growth, vision, immunity and organ function. Our bodies are unable to make vitamin A but a healthy diet including meat, dairy products and vegetables should be sufficient to maintain the body's nutritional needs. Read More..
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Some evidence has suggested that people who take vitamin A supplements may be increasing their risk of bone damage. Previous studies in mice have shown that short-term overdosing of vitamin A, at the equivalent of 13-142 times the recommended daily allowance in people, results in decreased bone thickness and an increased fracture risk after just 1-2 weeks.
This study is the first to examine the effects of lower vitamin A doses that are more equivalent to those consumed by people taking supplements, over longer time-periods.
In this study, Dr Ulf Lerner and colleagues from Sahlgrenska Academy at the University of Gothenburg, report that mice were given lower doses of vitamin A, equivalent to 4.5-13 times the RDA in humans, over a longer time period, also showed thinning of their bones after just 8 days, which progressed over the ten week study period.
Dr. Ulf Lerner commented, "Previous studies in rodents have shown that vitamin A decreases bone thickness, but these studies were performed with very high doses of vitamin A, over a short period of time. In our study, we have shown that much lower concentrations of vitamin A, a range more relevant for humans, still decreases rodent bone thickness and strength."
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Dr. Ulf Lerner cautions: "Overconsumption of vitamin A may be an increasing problem as many more people now take vitamin supplements. Overdose of vitamin A could be increasing the risk of bone weakening disorders in humans, but more studies are needed to investigate this. In the majority of cases, a balanced diet is perfectly sufficient to maintain the body's nutritional needs for vitamin A."
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