Towards Better Outcomes: Advancing Prevention and Treatment of Multiple Sclerosis

Risk of developing multiple sclerosis (MS) is influenced by a key factor, as discovered by researchers at the University of Virginia School of Medicine, offering new insights for preventing and treating the disease. The study findings are published in the scientific journal eLife (1^✔ ✔Trusted Source
The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate

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Researchers led by Mariano Garcia-Blanco, MD, Ph.D., chair of UVA’s Department of Microbiology, Immunology, and Cancer Biology, identified a series of processes in our cells that suppresses our risk for developing multiple sclerosis.

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Decoding the Risk Factors of Multiple Sclerosis

At the head of these processes, the scientists found, is a gene that acts as a master controller for many other genes important in our susceptibility to MS and in the proper functioning of our immune systems.

“It is remarkable that a protein that unwinds RNA is a central player in how we recognize our cells as our own, not to be confused with invading pathogens,” Garcia-Blanco said.

He noted that the new understanding could help lead to better, more targeted treatments: “While there are effective treatments for multiple sclerosis and other autoimmune diseases, most of these lead to general suppression of the immune system and makes patients susceptible to infections or incapable of responding well to vaccines.”

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Understanding Multiple Sclerosis

Multiple sclerosis is a potentially disabling autoimmune disorder in which the immune system begins to attack the sheath-like coverings that protect our nerves. The damage interrupts the nerves’ ability to transmit communications through the body.

This leads to symptoms such as muscle weakness and stiffness, spasms, fatigue, numbness, and difficulty moving. The disease is estimated to affect nearly a million Americans and almost 3 million people worldwide.

The new work from Garcia-Blanco and his collaborators sheds important light on how our immune systems are calibrated to prevent MS and identify several key places where things might go wrong.

For example, the researchers conclude that the master gene they identified, DDX39B, is an “important guardian of immune tolerance.”

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Game-Changing Finding

This means that it helps keeps the body’s immune response working at the appropriate levels so that the immune system doesn’t begin to attack the body’s own cells – as is the case in MS and other autoimmune diseases.

This master gene, the researchers found, directs the activity of another gene critical in the production of important immune cells called T regulatory cells (Tregs) previously linked to MS. This second gene, FOXP3, is already known to play a critical role in autoimmune disorders.

These new insights into how the immune system functions, or should function, help doctors and scientists better understand the underlying causes of multiple sclerosis and give them attractive targets in their efforts to develop new treatments and preventive measures.

Advancing Multiple Sclerosis Care

“In cases of autoimmune diseases, we would want to activate DDX39B with small-molecule agonists, for which there is strong pre-clinical precedent,” said Chloe Nagasawa, a graduate student with Garcia-Blanco and second author of the new scientific paper outlining the findings.

“Multiple sclerosis takes a massive toll on patients and society, affecting disproportionately young women, and to date, there is no cure. We believe that a basic understanding of molecular mechanisms underpinning immune tolerance will open paths to truly targeted therapy.”

Reference:

1. The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate - (https://elifesciences.org/articles/76927)

Source-Eurekalert