Researchers from the Sanford Burnham Prebys Medical Discovery Institute have found a technology that can help develop therapeutics for traumatic brain injuries.
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‘A peptide sequence of four amino acids, cysteine, alanine, glutamine, and lysine (CAQK) can carry drug-sized molecules and nanoparticles to the injured areas of the brain.
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Damage to the brain is caused due to falls, car crashes and sports. Though several researchers are being carried out to develop potential drug candidates that can reduce the effect of traumatic brain injuries, still it remains to be less efficient as they lead to secondary injuries such as inflammation, increasing free radicals, leading to cell death. Therefore, these researchers have come up with an alternative to inject therapeutics directly into the brain. A peptide sequence consisting of cysteine, alanine, glutamine, and lysine (CAQK) amino acids can carry drug-sized molecules and nanoparticles to the damaged areas of the brain.
"We have found a peptide sequence of four amino acids, cysteine, alanine, glutamine, and lysine (CAQK), that recognizes injured brain tissue. This peptide could be used to deliver treatments that limit the extent of damage," said Erkki Ruoslahti, senior author of the study.
Mild Traumatic Brain Injury Reduces Quality of Parent-Child Relationships
Mild traumatic brain injury or concussion in children between the ages of 0 to 5 years can reduce the development of new abilities like communication skills.
Mild traumatic brain injury or concussion in children between the ages of 0 to 5 years can reduce the development of new abilities like communication skills.
They conclude that their study results open up brain injuries for nanomedicine-based therapeutic approaches. This technology has been licensed by a startup company, called AivoCode, which was recently awarded a grant from the National Science Foundation to help along the development of the new technology.
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Every year in the United States, 1.7 million people experience a TBI and there is evidence that the rate of TBI is rising worldwide.
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