The efficacy and tolerability of Artesunate-Mefloquine fixed-dose combination (ASMQ FDC) was tested in children under 5 years of age with uncomplicated falciparum malaria.
Quiz on Malaria
Malaria is a common parasitic disease of the tropics, resulting in a million deaths every year. It is most commonly found in tropical countries. The symptoms of malaria include fever with chills, headache, muscle aches, tiredness, nausea, vomiting, and diarrhea. Malaria fatalities can be reduced if they are detected early and treated appropriately
Malaria is a common parasitic disease of the tropics, resulting in a million deaths every year. It is most commonly found in tropical countries. The symptoms of malaria include fever with chills, headache, muscle aches, tiredness, nausea, vomiting, and diarrhea. Malaria fatalities can be reduced if they are detected early and treated appropriately
- Day 28: ASMQ = 97.5% / AM-LM = 94.6 %
- Day 42: ASMQ = 93.6% / AM-LM = 92.1%
- Day 63 : ASMQ = 90.9% / AM-LM = 89.7%
No concerns of tolerability were demonstrated with ASMQ or with AL
- Very limited cases of vomiting, particularly early vomiting, led to treatment discontinuation in both treatments
- No unexpected adverse effects events were noted
Data in Africa on the combination (AS+MQ non fixed-dose) had previously demonstrated high efficacy, acceptable safety, and tolerability. Obtaining further clinical data on the combination of Artesunate with Mefloquine in children in Africa was recommended by the World Health Organization (WHO) and its Prequalification Programme. ASMQ FDC is one of several recommended ACTs that aim to delay the emergence of resistance to the individual drug components of the combination treatment. The treatment regimen is easier to administer by the fact that the two drugs are combined into one tablet that only requires once-a-day administration over three days (as compared to twice-a-day over three days for AL).
'The ASMQ fixed-dose combination has proven its importance among tools recommended by the WHO and can now be available to African children suffering from uncomplicated falciparum malaria', said Dr Bernard Pécoul, Executive Director of DNDi. 'Considering that a child dies every 30 seconds from malaria, we hope that governments in affected African countries will now take up this additional treatment option to ensure their populations have access to several ACTs.'
ASMQ FDC was originally developed by DNDi and the Brazilian government-owned pharmaceutical company Farmanguinhos/Fiocruz and was registered in Brazil in 2008. A South-South technology transfer between Farmanguinhos and Cipla, India, was achieved in 2010 to facilitate the implementation of ASMQ FDC worldwide and was pre-qualified by the WHO Prequalification Programme in 2012. ASMQ FDC is currently registered in Brazil, India, Myanmar, Malaysia, Vietnam, Tanzania, and Niger, and pending registration in 17 countries in Africa and Asia.
New Herbal Remedy to Fight Malaria
Recent research has shown that the powdered dried leaves of Artemisia annua is much more effective in treating malaria than the purified form of the drug artemisinin.
Recent research has shown that the powdered dried leaves of Artemisia annua is much more effective in treating malaria than the purified form of the drug artemisinin.
Second Door Discovered in War Against Mosquito-Borne Diseases
A new study has discovered yet another molecular door, which when put to use, may signal an end to mosquito-borne illnesses.
A new study has discovered yet another molecular door, which when put to use, may signal an end to mosquito-borne illnesses.
